Who is the vessel of mercy, and who is the vessel of wrath?

Rom. 9:21 Hath not the potter power over the clay, of the same lump to make one vessel unto honour, and another unto dishonour?
22 What if God, willing to shew his wrath, and to make his power known, endured with much longsuffering the vessels of wrath fitted to destruction:
23 And that he might make known the riches of his glory on the vessels of mercy, which he had afore prepared unto glory,

Did God make the vessels of wrath, intending them for destruction?
Can a vessel of mercy become a vessel of wrath and vice versa?
What is the spiritual application?